No good explanation can predict the outcome, or the probability of an outcome, of a phenomenon whose course is going to be significantly affected by the creation of new knowledge. This is a fundamental limitation on the reach of scientific prediction, and, when planning for the future

No good explanation can predict the outcome, or the probability of an outcome, of a phenomenon whose course is going to be significantly affected by the creation of new knowledge. This is a fundamental limitation on the reach of scientific prediction, and, when planning for the future, it is vital to come to terms with it.